Journal: Hepatology Communications

Article Title: Hyperoxidized Albumin Modulates Platelets and Promotes Inflammation Through CD36 Receptor in Severe Alcoholic Hepatitis

doi: 10.1002/hep4.1440

Figure Lengend Snippet: Validation of platelet functionality in SAH. (A) Platelet activation/aggregation in SAH histogram shows the percent expression of PAC‐1, P‐selectin (CD62p), and intracellular Ca +2 (secretion) in SAH and HC. (B) Increased expression (relative change) of various mRNA in SAH platelets linked to platelet and complement activation. Protein expression of Gp2b/3a/β‐actin ratio in platelets of patients with SAH. Results expressed as mean ± SEM (* P < 0.05, ** P < 0.01 for SAH versus HC). (C) Patients with SAH showed higher plasma levels of PF‐4 (65.85 ± 0.9457 versus 81.13 ± 6.595 ng/mL, P < 0.02), P‐selectin (6.360 ± 0.1639 versus 10.118 ± 2.1492 ng/mL, P < 0.0001), and soluble cluster of differentiation 40 ligand (1,726 ± 134.4 versus 2,528 ± 1.525.4 pg/mL, P < 0.05). Circulating levels of PF‐4, P‐selectin, and sCD40L correlated with the MELD score in SAH (r > 0.5, P < 0.05). (D) Representative western blot of SNARE complex proteins in platelets isolated from SAH versus HC (n = 5). Results are expressed as mean ± SEM (* P < 0.05, ** P < 0.01, *** P < 0.001 as indicated).

Article Snippet: Plasma‐citrated blood samples were centrifuged for 15 minutes at 3,000 g , and levels of PF‐4 (E‐EL‐H2216; Elabscience, Houston, TX), P‐selectin (E‐EL‐H0917; Elabscience), and sCD40L (E‐EL‐H0035; Elabscience) were measured.

Techniques: Biomarker Discovery, Activation Assay, Expressing, Clinical Proteomics, Western Blot, Isolation

Journal: Antioxidants

Article Title: Sex-Related Differences in Oxidative, Platelet, and Vascular Function in Chronic Users of Heat-not-Burn vs. Traditional Combustion Cigarettes

doi: 10.3390/antiox11071237

Figure Lengend Snippet: Overall cohort.

Article Snippet: The plasmatic levels of soluble CD40 ligand (sCD40L) were measured by a commercial enzymatic kit (Cusabio, Houston, TX, USA).

Techniques:

Journal: Antioxidants

Article Title: Sex-Related Differences in Oxidative, Platelet, and Vascular Function in Chronic Users of Heat-not-Burn vs. Traditional Combustion Cigarettes

doi: 10.3390/antiox11071237

Figure Lengend Snippet: Non-smokers.

Article Snippet: The plasmatic levels of soluble CD40 ligand (sCD40L) were measured by a commercial enzymatic kit (Cusabio, Houston, TX, USA).

Techniques:

Journal: Antioxidants

Article Title: Sex-Related Differences in Oxidative, Platelet, and Vascular Function in Chronic Users of Heat-not-Burn vs. Traditional Combustion Cigarettes

doi: 10.3390/antiox11071237

Figure Lengend Snippet: Chronic users of traditional combustion cigarettes.

Article Snippet: The plasmatic levels of soluble CD40 ligand (sCD40L) were measured by a commercial enzymatic kit (Cusabio, Houston, TX, USA).

Techniques:

Journal: Antioxidants

Article Title: Sex-Related Differences in Oxidative, Platelet, and Vascular Function in Chronic Users of Heat-not-Burn vs. Traditional Combustion Cigarettes

doi: 10.3390/antiox11071237

Figure Lengend Snippet: Chronic users of heat-not-burn cigarettes.

Article Snippet: The plasmatic levels of soluble CD40 ligand (sCD40L) were measured by a commercial enzymatic kit (Cusabio, Houston, TX, USA).

Techniques:

Journal: Antioxidants

Article Title: Sex-Related Differences in Oxidative, Platelet, and Vascular Function in Chronic Users of Heat-not-Burn vs. Traditional Combustion Cigarettes

doi: 10.3390/antiox11071237

Figure Lengend Snippet: Multivariable regression models, with and without interaction term *.

Article Snippet: The plasmatic levels of soluble CD40 ligand (sCD40L) were measured by a commercial enzymatic kit (Cusabio, Houston, TX, USA).

Techniques: